Artichaud – Monograph

SOURCE- HEALTH CANADA: Compendium of Medicinal Ingredients Nomenclature

Date: 2008-04-10

Name of NHPID

Cynara cardunculus

Proper name(s)

• Cynara cardunculus L. (Asteraceae)
• Cynara scolymus L. (Asteraceae)

Common name(s)

• Artichoke
• Common artichoke

Material of origin

Leaf

Route of administration

Oral

Dosage form(s)

Depending on the route(s) of administration. Foods and food-like dosage forms such as bars, chewing gum or beverages are excluded from this monograph.

Recommended use(s) or purpose(s)

Statement(s) specifying the following:

• Used in herbal medicine to help relieve digestive disorders, such as dyspepsia
• Used in herbal medicine to help stimulate the secretion of bile (choleretic)

Dose(s)

Adults:

Preparation:Dry, powder, decoction and infusion + all unstandardized extracts

Dose(s): 1.5 – 10 Grams per day, dried leaves

Refer to Appendix 1 for relevant examples of dose and frequency preparations for use, as referenced above. The purpose of Annex 1 is to provide guidance to industry.

Duration of use

Statement not required

Mention of risks

Statement(s) specifying the following:

Precaution(s) and warning(s):

• Consult a health care practitioner prior to use if you have gallstones
• Consult a health care practitioner before use if you are pregnant
• Consult a health care practitioner if symptoms persist.
• Consult a health care practitioner if symptoms worsen.

Contre-indication(s):

• Do not use if allergic to the Asteraceae/Compounds/Daisies family
• Do not use if you have bile duct obstruction

Known adverse reaction(s):
Hypersensitivity (e.g. allergy) may occur. If this is the case, discontinue use

Non-medicinal ingredients

Must be selected from the current Natural Health Products Ingredient Database and must meet the restrictions defined in the database.

Specifications

• Finished product specifications must be established in accordance with the requirements outlined in the NHPD’s Natural Health Product Quality Reference Guide.
• The medicinal ingredient must comply with the requirements set out in the Natural Health Products Ingredient Database (NHPID).
• The medicinal ingredient may meet the specifications set out in the Artichoke Leaf monograph published in the British Pharmacopoeia (BP).

Appendix 1: Relevant Examples of Dose and Frequency Preparations

Dried leaf:

6 g, per day (Blumenthal et al. 2000)

Infusion:

5 to 10 g of dried leaves, per day (ESCOP 2003)

Dye:

dry weight equivalent of 1.5 to 4 g, per day
(1:2, 3 to 8 ml) (Mills and Bone 2005)

Aqueous dry extract:

• dry weight equivalent of 4.5 to 9 g, per day (Bradley 2006)
• dry weight equivalent of 5 to 10 g per day (ESCOP 2003)