Phytonutrient Blog

Artichaud – Monograph

SOURCE- HEALTH CANADA: Compendium of Medicinal Ingredients Nomenclature

Date: 2008-04-10

Name of NHPID

Cynara cardunculus

Proper name(s)

  • Cynara cardunculus L. (Asteraceae)
  • Cynara scolymus L. (Asteraceae)

Common name(s)

  • Artichoke
  • Common artichoke

Material of origin


Route of administration


Dosage form(s)

Depending on the route(s) of administration. Foods and food-like dosage forms such as bars, chewing gum or beverages are excluded from this monograph.

Recommended use(s) or purpose(s)

Statement(s) specifying the following:

  • Used in herbal medicine to help relieve digestive disorders, such as dyspepsia
  • Used in herbal medicine to help stimulate the secretion of bile (choleretic)



Preparation:Dry, powder, decoction and infusion + all unstandardized extracts

Dose(s): 1.5 – 10 Grams per day, dried leaves

Refer to Appendix 1 for relevant examples of dose and frequency preparations for use, as referenced above. The purpose of Annex 1 is to provide guidance to industry.

Duration of use

Statement not required

Mention of risks

Statement(s) specifying the following:

Precaution(s) and warning(s):

  • Consult a health care practitioner prior to use if you have gallstones
  • Consult a health care practitioner before use if you are pregnant
  • Consult a health care practitioner if symptoms persist.
  • Consult a health care practitioner if symptoms worsen.


  • Do not use if allergic to the Asteraceae/Compounds/Daisies family
  • Do not use if you have bile duct obstruction

Known adverse reaction(s):
Hypersensitivity (e.g. allergy) may occur. If this is the case, discontinue use

Non-medicinal ingredients

Must be selected from the current Natural Health Products Ingredient Database and must meet the restrictions defined in the database.


  • Finished product specifications must be established in accordance with the requirements outlined in the NHPD’s Natural Health Product Quality Reference Guide.
  • The medicinal ingredient must comply with the requirements set out in the Natural Health Products Ingredient Database (NHPID).
  • The medicinal ingredient may meet the specifications set out in the Artichoke Leaf monograph published in the British Pharmacopoeia (BP).

Appendix 1: Relevant Examples of Dose and Frequency Preparations

Dried leaf:

6 g, per day (Blumenthal et al. 2000)


5 to 10 g of dried leaves, per day (ESCOP 2003)


dry weight equivalent of 1.5 to 4 g, per day
(1:2, 3 to 8 ml) (Mills and Bone 2005)

Aqueous dry extract:

  • dry weight equivalent of 4.5 to 9 g, per day (Bradley 2006)
  • dry weight equivalent of 5 to 10 g per day (ESCOP 2003)



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